VU0119498

VU0119498 is a pan Gq muscarinic acetylcholine receptor (mAChR) M1, M3, M5 positive allosteric modulator (PAM) with EC50 of 6.1 μM, 6.4 μM, 4.1 μM, respectively.

Product information

CAS Number: 79183-37-2

Molecular Weight: 316.15

Formula: C15H10BrNO2

Synonym:

VU 0119498

VU-0119498

Chemical Name: 1-[(4-bromophenyl)methyl]indole-2,3-dione

Smiles: O=C1C2=CC=CC=C2N(CC2C=CC(Br)=CC=2)C1=O

InChiKey: DELLOEULSHGYCG-UHFFFAOYSA-N

InChi: InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 50 mg/mL (158.15 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Thomas M Bridges, et al. Bioorg Med Chem Lett. 2010 Mar 15;

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