详情描述
Emodin (from Rheum emodi, a Himalayan rhubarb) is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, buckthorn and Japanese knotweed (Fallopia japonica syn. Polygonum cuspidatum). Emodin is being studied as a potential agent that could reduce the impact of type 2 diabetes. It is a potent selective inhibitor of the enzyme 11β-HSD1. In studies in obese mice, emodin limits the effect of glucocorticoids and may therefore ameliorate diabetes and insulin resistance. Emodin is also shown to block cytomegalovirus infections as well as herpes simplex.
Product information
CAS Number: 518-82-1
Molecular Weight: 270.24
Formula: C15H10O5
Synonym:
Emodol
Frangula emodin
HSDB 7093
NSC 408120
NSC 622947
rheum emodin
Schuttgelb
Persian Berry Lake
3-methyl-1, 6, 8-trihydroxyanthraquinone
Chemical Name: 1,3,8-trihydroxy-6-methylanthracene-9,10-dione
Smiles: CC1=CC(O)=C2C(=C1)C(=O)C1=CC(O)=CC(O)=C1C2=O
InChiKey: RHMXXJGYXNZAPX-UHFFFAOYSA-N
InChi: InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 54 mg/mL(199.82 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Feng Y, et al. Br J Pharmacol, 2010,161(1):113-26.
Products are for research use only. Not for human use.