Luteolin

Luteolin is a flavone, a type of flavonoid. Like all flavonoids, it has a yellow crystalline appearance. Luteolin belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. Luteolin possesses many beneficial properties including antioxidant, anti- inflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions.

Product information

CAS Number: 491-70-3

Molecular Weight: 286.24

Formula: C15H10O6

Synonym:

BRN 0292084

C.I. 75590

C.I. Natural Yellow 2

CCRIS 3790

Cyanidenon 1470

Digitoflavone

Flacitran

Luteoline

Luteolol

Salifazide

Luteolin

Chemical Name: 2-(3, 4-Dihydroxyphenyl)-5, 7-dihydroxy-4-benzopyrone

Smiles: OC1=CC=C(C=C1O)C1=CC(=O)C2=C(C=C(O)C=C2O)O1

InChiKey: IQPNAANSBPBGFQ-UHFFFAOYSA-N

InChi: InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 57 mg/mL (199.13 mM) Ethanol (warmed with 50ºC water bath) 3 mg/mL (10.48 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha.

In Vivo:

LD50: Mice >2500mg/kg (i.g.)

References:

1. Xagorari A, et al. J Pharmacol Exp Ther, 2001, 296(1), 181-187.
2. Yu MC, et al. Eur J Pharmacol, 2010, 627(1-3), 269-275.

Products are for research use only. Not for human use.