Parthenolide((-)-Parthenolide)

Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.

Product information

CAS Number: 20554-84-1

Molecular Weight: 248.32

Formula: C15H20O3

Synonym:

NSC-157035

NSC 157035

NSC157035

Chemical Name: (1S, 2R, 4R, 11S)-4, 8-dimethyl-12-methylidene-3, 14-dioxatricyclo[9.3.0.0, ]tetradec-7-en-13-one

Smiles: CC1CC[C@@H]2[C@H](OC(=O)C2=C)[C@H]2O[C@]2(C)CCC=1 |c:19|

InChiKey: KTEXNACQROZXEV-ZRPLFPEYSA-N

InChi: InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-/t11-,12-,13+,15+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 49 mg/mL(197.32 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Gopal YN, et al. Mol Cancer Ther. 2009, 8(3):552-62.
2. Sheehan M, et al. Mol Pharmacol. 2002, 61(5):953-63.
3. Gopal YN, et al. Chem Biol, 2007,14(7):813-23.

Products are for research use only. Not for human use.