详情描述
6H05 TFA is a selective and allosteric inhibitor of oncogenic K-Ras(G12C) .
Product information
CAS Number: 1469338-01-9
Molecular Weight: 476.12
Formula: C20H30ClN3O2S3
Chemical Name: 1-{2-[(4-chlorophenyl)sulfanyl]acetyl}-N-(2-{[2-(dimethylamino)ethyl]disulfanyl}ethyl)piperidine-4-carboxamide
Smiles: CN(C)CCSSCCNC(=O)C1CCN(CC1)C(=O)CSC1C=CC(Cl)=CC=1
InChiKey: WEEYMZOUPNIHLG-UHFFFAOYSA-N
InChi: InChI=1S/C20H30ClN3O2S3/c1-23(2)12-14-29-28-13-9-22-20(26)16-7-10-24(11-8-16)19(25)15-27-18-5-3-17(21)4-6-18/h3-6,16H,7-15H2,1-2H3,(H,22,26)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Ostrem J M , Peters U , Sos M L , et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions[J]. Nature, 2013, 503(7477):548-551.
- Lu S , Li S , Zhang J . Harnessing Allostery: A Novel Approach to Drug Discovery[J]. Medicinal Research Reviews, 2014, 34(6):1242-1285.
Products are for research use only. Not for human use.