Cobimetinib Racemate

Cobimetinib Racemate is a selective inhibitor of MEK. GDC-0973 is also known as a mitogen-activated protein kinase, is a key component of the RAS/RAF/MEK/ERK pathway.

Product information

CAS Number: 934662-91-6

Molecular Weight: 531.31

Formula: C21H21F3IN3O2

Synonym:

GDC-0973 racemate

XL-518

GDC 0973

Chemical Name: 1-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl}-3-(piperidin-2-yl)azetidin-3-ol

Smiles: OC1(CN(C1)C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F)C1CCCCN1

InChiKey: BSMCAPRUBJMWDF-UHFFFAOYSA-N

InChi: InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9.

Products are for research use only. Not for human use.