Brivaracetam

Brivaracetam is discontinued (DEA controlled susbtance). Brivaracetam, also known as UCB 34714, is a chemical analog of levetiracetam, is a racetam derivative with anticonvulsant (antiepileptic) properties approved for the treatment of epilepsy. Brivaracetam was approved in 2/18/2016 to treat partial onset seizures in patients age 16 years and older with epilepsy. This product is a controlled substance.

Product information

CAS Number: 357336-20-0

Molecular Weight: 212.29

Formula: C11H20N2O2

Synonym:

UCB 34714

UCB34714

UCB-34714

Chemical Name: (2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl]butanamide

Smiles: CCC[C@@H]1CC(=O)N(C1)[C@@H](CC)C(N)=O

InChiKey: MSYKRHVOOPPJKU-BDAKNGLRSA-N

InChi: InChI=1S/C11H20N2O2/c1-3-5-8-6-10(14)13(7-8)9(4-2)11(12)15/h8-9H,3-7H2,1-2H3,(H2,12,15)/t8-,9+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Steinhoff BJ, Bacher M, Blickhan M, Bernedo V, Dietmann D, Intravooth T, Kornmeier R, Kurth C, Mahn P, Schneider M, Stockinger J, Staack AM. Is brivaracetam-induced elevation of carbamazepine-epoxide levels common and clinically relevant? - A case series. Epilepsy Res. 2019 Nov 6;159:106236.
2. Fonseca E, Guzmán L, Quintana M, Abraira L, Santamarina E, Salas-Puig X, Toledo M. Efficacy, retention, and safety of brivaracetam in adult patients with genetic generalized epilepsy. Epilepsy Behav. 2019 Nov 12;102:106657.
3. Nissenkorn A, Tzadok M, Bar-Yosef O, Ben-Zeev B. Treatment with brivaracetam in children - The experience of a pediatric epilepsy center. Epilepsy Behav. 2019 Dec;101(Pt A):106541.

Products are for research use only. Not for human use.