详情描述
CC-401, also known as JNK-401, is a potent, selective, ATP-competitive pan-JNK inhibitor that decreases hepatic necrosis and apoptosis, significantly reduces tubular apoptosis in the obstructed kidney, sensitizes hypoxic colon cancer cells to DNA-damaging agents, and potentiates the effect of bevacizumab and oxaliplatin in HT29-derived mouse xenografts. CC-401 Promotes β-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition.
Product information
CAS Number: 1438391-30-0
Molecular Weight: 424.93
Formula: C22H25ClN6O
Chemical Name: 3-{3-[2-(piperidin-1-yl)ethoxy]phenyl}-5-(1H-1,2,4-triazol-5-yl)-1H-indazole hydrochloride
Smiles: Cl.C(CN1CCCCC1)OC1=CC(=CC=C1)C1=NNC2=CC=C(C=C21)C1NN=CN=1
InChiKey: OIBVXKYKWOUGAO-UHFFFAOYSA-N
InChi: InChI=1S/C22H24N6O.ClH/c1-2-9-28(10-3-1)11-12-29-18-6-4-5-16(13-18)21-19-14-17(22-23-15-24-27-22)7-8-20(19)25-26-21;/h4-8,13-15H,1-3,9-12H2,(H,25,26)(H,23,24,27);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.