详情描述
CCG-63802 is a potent and reversible inhibitor of RGS protein. CCG-63802 inhibits the interaction between RGS4 and Galpha(o) with an IC(50) value in the low micromolar range. CCG-63802 shows selectivity among RGS proteins with a potency order of RGS 4 > 19 = 16 > 8 >> 7. CCG-63802 inhibits the GTPase accelerating protein activity of RGS4, and thermal stability studies demonstrate binding to the RGS but not to Galpha(o). CCG-63802 represents a useful step toward the development of chemical tools for the study of RGS physiology.
Product information
CAS Number: 620112-78-9
Molecular Weight: 450.51
Formula: C26H18N4O2S
Chemical Name: (2E)-2-(1,3-benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile
Smiles: CC1=CC=CN2C(=O)C(/C=C(\C#N)/C3=NC4=CC=CC=C4S3)=C(N=C21)OC1=CC(C)=CC=C1
InChiKey: VFSVKVQMZDJFQX-NBVRZTHBSA-N
InChi: InChI=1S/C26H18N4O2S/c1-16-7-5-9-19(13-16)32-24-20(26(31)30-12-6-8-17(2)23(30)29-24)14-18(15-27)25-28-21-10-3-4-11-22(21)33-25/h3-14H,1-2H3/b18-14+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.