Caroverine HCl

Caroverine HCl is a nonselective NMDA and AMPA glutamate receptor antagonist, also acting as a class B calcium-channel-blocker. Pharmacologically, it has been described as a nonspecific calcium channel blocker and as an antagonist of both non-NMDA and NMDA glutamate receptors. It was discovered in Austria in the 1950s[3]

Product information

CAS Number: 55750-05-5

Molecular Weight: 401.93

Formula: C22H28ClN3O2

Chemical Name: 1-(2-(diethylamino)ethyl)-3-(4-methoxybenzyl)quinoxalin-2(1H)-one hydrochloride

Smiles: Cl.COC1C=CC(CC2=NC3=CC=CC=C3N(CCN(CC)CC)C2=O)=CC=1

InChiKey: JRNWTJUIMRLKBV-UHFFFAOYSA-N

InChi: InChI=1S/C22H27N3O2.ClH/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17;/h6-13H,4-5,14-16H2,1-3H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (248.80 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) and noradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta.

In Vivo:

Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat.

References:

1. Chen Z, et, al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. Jan-Feb 2003;8(1):49-56.
2. Denk DM, et, al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997 Nov;117(6):825-30.
3. Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8.

Products are for research use only. Not for human use.