β-Naphthoflavone-CH2-Br

β-Naphthoflavone-CH2-Br (β-NF-CH2-Br) is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br can be used to synthesize the PROTAC β-NF-JQ1(HY-130256).

Product information

CAS Number: 1282513-77-2

Molecular Weight: 365.22

Formula: C20H13BrO2

Synonym:

β-NF-CH2-Br

Chemical Name: 3-[4-(bromomethyl)phenyl]-1H-benzo[f]chromen-1-one

Smiles: O=C1C=C(OC2=CC=C3C=CC=CC3=C21)C1C=CC(CBr)=CC=1

InChiKey: JKXPXUCDLPRQNA-UHFFFAOYSA-N

InChi: InChI=1S/C20H13BrO2/c21-12-13-5-7-15(8-6-13)19-11-17(22)20-16-4-2-1-3-14(16)9-10-18(20)23-19/h1-11H,12H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Ohoka N, et al. Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins. ACS Chem Biol. 2019 Oct 16.

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