8-Bromo-cAMP sodium salt

8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA).

Product information

CAS Number: 76939-46-3

Molecular Weight: 430.08

Formula: C10H10BrN5NaO6P

Synonym:

8-Br-Camp sodium salt

Chemical Name: (4aR, 6R, 7R, 7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxy-2-(sodiooxy)-hexahydro-2-furo[3, 2-d][1, 3, 2]dioxaphosphinin-2-one

Smiles: NC1=NC=NC2=C1N=C(Br)N2[C@@H]1O[C@@H]2COP(=O)(O[Na])O[C@H]2[C@H]1O

InChiKey: DMRMZQATXPQOTP-GWTDSMLYSA-M

InChi: InChI=1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (290.64 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

8-Bromo-cAMP sodium salt is a brominated derivative of cyclic AMP. 8-Bromo-cAMP sodium salt enhances the efficiency of cellular reprogramming. 8-Bromo-cAMP sodium salt improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. 8-Bromo-cAMP sodium salt inhibits proliferation, induce differentiation and apoptosis in a malignant glioma cell line (A-172) and an esophageal cancer cell line (Eca-109).

References:

1. Wang Y, et al. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011 Jun;7(2):331-41.

Products are for research use only. Not for human use.