Cearoin

Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK.

Product information

CAS Number: 52811-37-7

Molecular Weight: 244.24

Formula: C14H12O4

Chemical Name: 2-benzoyl-5-methoxybenzene-1, 4-diol

Smiles: COC1=CC(O)=C(C=C1O)C(=O)C1C=CC=CC=1

InChiKey: NFJVELXCUBWAFL-UHFFFAOYSA-N

InChi: InChI=1S/C14H12O4/c1-18-13-8-11(15)10(7-12(13)16)14(17)9-5-3-2-4-6-9/h2-8,15-16H,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Cearoin (10-80 μM) induces cell death in a dose-dependent manner. Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells. Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process.

References:

1. Tonking Bastola, et al. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells. Molecules. 2017 Feb 6;22(2):242.

Products are for research use only. Not for human use.