(+)-CBI-CDPI2

(+)-CBI-CDPI2 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI2 is an antibody drug conjugates (ADCs) toxin.

Product information

CAS Number: 128300-15-2

Molecular Weight: 608.65

Formula: C36H28N6O4

Chemical Name: 7-{7-[(1R, 13S)-8-oxo-11-azatetracyclo[8.4.0.0, .0, ]tetradeca-2, 4, 6, 9-tetraene-11-carbonyl]-1H, 2H, 3H, 6H-pyrrolo[3, 2-e]indole-3-carbonyl}-1H, 2H, 3H, 6H-pyrrolo[3, 2-e]indole-3-carboxamide

Smiles: NC(=O)N1CCC2C1=CC=C1NC(=CC=21)C(=O)N1CCC2C1=CC=C1NC(=CC=21)C(=O)N1C[C@H]2C[C@]32C1=CC(=O)C1=CC=CC=C31

InChiKey: RFHRJOHMDOUTEF-NNIOICJLSA-N

InChi: InChI=1S/C36H28N6O4/c37-35(46)41-12-10-20-23-13-27(38-26(23)6-8-30(20)41)33(44)40-11-9-19-22-14-28(39-25(22)5-7-29(19)40)34(45)42-17-18-16-36(18)24-4-2-1-3-21(24)31(43)15-32(36)42/h1-8,13-15,18,38-39H,9-12,16-17H2,(H2,37,46)/t18-,36-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Boger DL, et al. Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity. Bioorg Med Chem. 1994 Feb;2(2):115-35.

Products are for research use only. Not for human use.