(+)-CBI-CDPI1

(+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI1 is an antibody drug conjugates (ADCs) toxin.

Product information

CAS Number: 128300-14-1

Molecular Weight: 424.45

Formula: C25H20N4O3

Chemical Name: 7-[(1R, 13S)-8-oxo-11-azatetracyclo[8.4.0.0, .0, ]tetradeca-2, 4, 6, 9-tetraene-11-carbonyl]-1H, 2H, 3H, 6H-pyrrolo[3, 2-e]indole-3-carboxamide

Smiles: NC(=O)N1CCC2C1=CC=C1NC(=CC=21)C(=O)N1C[C@H]2C[C@]32C1=CC(=O)C1=CC=CC=C31

InChiKey: ZYNHKKZUGALOOV-YMXBGEKHSA-N

InChi: InChI=1S/C25H20N4O3/c26-24(32)28-8-7-14-16-9-19(27-18(16)5-6-20(14)28)23(31)29-12-13-11-25(13)17-4-2-1-3-15(17)21(30)10-22(25)29/h1-6,9-10,13,27H,7-8,11-12H2,(H2,26,32)/t13-,25-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Boger DL, et al. Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity. Bioorg Med Chem. 1994 Feb;2(2):115-35.

Products are for research use only. Not for human use.