(E)-AG 99

(E)-AG 99 ((E)-Tyrphostin 46) is a potent EGFR inhibitor.

Product information

CAS Number: 122520-85-8

Molecular Weight: 204.18

Formula: C10H8N2O3

Synonym:

(E)-Tyrphostin 46

(E)-Tyrphostin AG 99

Chemical Name: (E)-2-cyano-3-(3, 4-dihydroxyphenyl)acrylamide

Smiles: NC(=O)/C(=C/C1=CC(O)=C(O)C=C1)/C#N

InChiKey: USOXQZNJFMKTKJ-XVNBXDOJSA-N

InChi: InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 41 mg/mL(200.8 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

(E)-AG 99 effectively blocks tyrosine phosphorylation of p145met and promotes cell death accompanied by activation of caspase-like proteases.

References:

1. Yamamoto N, et al. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J Cell Sci. 2006 Nov 15;119(Pt 22):4623-33.

Products are for research use only. Not for human use.