(-)-Zuonin A

(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively.

Product information

CAS Number: 84709-25-1

Molecular Weight: 340.37

Formula: C20H20O5

Synonym:

D-Epigalbacin

Chemical Name: 5-[(2S, 3R, 4S, 5S)-5-(2H-1, 3-benzodioxol-5-yl)-3, 4-dimethyloxolan-2-yl]-2H-1, 3-benzodioxole

Smiles: C[C@@H]1[C@H](O[C@@H]([C@@H]1C)C1=CC2OCOC=2C=C1)C1=CC2OCOC=2C=C1

InChiKey: QFUXQRHAJWXPGP-YLYZPZNOSA-N

InChi: InChI=1S/C20H20O5/c1-11-12(2)20(14-4-6-16-18(8-14)24-10-22-16)25-19(11)13-3-5-15-17(7-13)23-9-21-15/h3-8,11-12,19-20H,9-10H2,1-2H3/t11-,12+,19-,20-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

(−)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs. (−)-zuonin A inhibits the activation and phosphorylation of JNK by MKK4 and MKK7.

References:

1. Tamer S. Kaoud, et al. Manipulating JNK Signaling with (−)-zuonin A. ACS Chem Biol. 2012 Nov 16; 7(11): 1873–1883.

Products are for research use only. Not for human use.