(-)-Epipodophyllotoxin

(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro.

Product information

CAS Number: 4375-07-9

Molecular Weight: 414.41

Formula: C22H22O8

Chemical Name: (10R, 11R, 15R, 16S)-16-hydroxy-10-(3, 4, 5-trimethoxyphenyl)-4, 6, 13-trioxatetracyclo[7.7.0.0, .0, ]hexadeca-1, 3(7), 8-trien-12-one

Smiles: COC1=CC(=CC(OC)=C1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O)C2=CC3OCOC=3C=C21

InChiKey: YJGVMLPVUAXIQN-LGWHJFRWSA-N

InChi: InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Magedov IV, et, al. Reengineered epipodophyllotoxin. Chem Commun (Camb). 2012 Oct 28; 48(84): 10416-8.

Products are for research use only. Not for human use.