β-Pompilidotoxin TFA

β-Pompilidotoxin TFA (β-PMTX TFA), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells.

Product information

Molecular Weight: 1671.90

Formula: C73H125F3N22O19

Synonym:

β-PMTX TFA

Chemical Name: (6S, 9S, 12S, 15S, 21S, 24S, 27S)-1, 1, 6-triamino-27-((4S, 7S, 10S, 13S, 16S)-19-amino-4-carbamoyl-7-(3-(diaminomethyleneamino)propyl)-10-(hydroxymethyl)-13-isobutyl-2-methyl-6, 9, 12, 15, 19-pentaoxo-5, 8, 11, 14-tetraazanonadecan-16-ylcarbamoyl)-12-(4-aminobutyl)-24-benzyl-9, 15-di-sec-butyl-21-isobutyl-7, 10, 13, 16, 19, 22, 25-heptaoxo-2, 8, 11, 14, 17, 20, 23, 26-octaazanonacos-1-en-29-oic acid compound with 2, 2, 2-trifluoroacetic acid

Smiles: CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCN=C(N)N)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(N)=O.OC(=O)C(F)(F)F

InChiKey: NHACPCAIGDEPCI-JYIROUKOSA-N

InChi: InChI=1S/C71H124N22O17.C2HF3O2/c1-11-40(9)56(93-62(103)44(23-16-17-27-72)86-69(110)57(41(10)12-2)92-59(100)43(73)22-18-28-80-70(76)77)68(109)82-35-54(96)83-48(31-38(5)6)63(104)89-50(33-42-20-14-13-15-21-42)65(106)90-51(34-55(97)98)66(107)85-46(25-26-53(74)95)61(102)88-49(32-39(7)8)64(105)91-52(36-94)67(108)84-45(24-19-29-81-71(78)79)60(101)87-47(58(75)99)30-37(3)4;3-2(4,5)1(6)7/h13-15,20-21,37-41,43-52,56-57,94H,11-12,16-19,22-36,72-73H2,1-10H3,(H2,74,95)(H2,75,99)(H,82,109)(H,83,96)(H,84,108)(H,85,107)(H,86,110)(H,87,101)(H,88,102)(H,89,104)(H,90,106)(H,91,105)(H,92,100)(H,93,103)(H,97,98)(H4,76,77,80)(H4,78,79,81);(H,6,7)/t40-,41-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,56-,57-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

β-Pompilidotoxin TFA (β-PMTX TFA) increases resurgent current in wild-type neurons and induced resurgent current in med neurons. β-Pompilidotoxin TFA (10 μM) modestly but significantly increased the decay time constant (τdecay) of currents evoked by a step from -90 to 0 mV from 0.52 to 0.73 msec in wild-type Purkinje cells.

References:

1. Tina M Grieco, et al. Production of resurgent current in NaV1.6-null Purkinje neurons by slowing sodium channel inactivation with beta-pompilidotoxin. J Neurosci. 2004 Jan 7;24(1):35-42.

Products are for research use only. Not for human use.