BRD9757 --- HDAC6 Inhibitor

BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6. BRD9757 has >20-fold selectivity for class I and > 400-fold selectivity for class II HDACs tested. BRD9757 is absence of a surface-binding motif. It demonstrates that high selectivity and potent inhibition of HDAC6 can be achieved through careful choice of linker element only. BRD9757 can be used as a useful tool for probing the biological functions and relevance of the different HDAC isoforms, and serves as a basis for new selective inhibitors of other HDAC isoforms.

Product information

CAS Number: 1423058-85-8

Molecular Weight: 127.14

Formula: C6H9NO2

Chemical Name: N-hydroxycyclopent-1-enecarboxamide

Smiles: ONC(=O)C1CCCC=1

InChiKey: RYYGSXXWQSXKRP-UHFFFAOYSA-N

InChi: InChI=1S/C6H9NO2/c8-6(7-9)5-3-1-2-4-5/h3,9H,1-2,4H2,(H,7,8)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

BRD9757 was suggested to be used at 10 µM final concentration in vitro and in cellular assays.

References:

1. Wagner FF, et al. Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif. (2013) J Med Chem. 56 (4), 1772–1776.

Products are for research use only. Not for human use.