AMI-1, Histone Methyltransferase Inhibitor

AMI-1 is a potent and selective arginine methyltransferase inhibitor, is also a potent scavenger of NADPH-oxidase-derived superoxide. AMI-1 can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements.

Product information

CAS Number: 20324-87-2

Molecular Weight: 548.45

Formula: C21H14N2Na2O9S2

Chemical Name: sodium 7,7'-(carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonate)

Smiles: [Na+].[Na+].[O-]S(=O)(=O)C1C=C(O)C2=CC=C(C=C2C=1)NC(=O)NC1=CC2=CC(=CC(O)=C2C=C1)S([O-])(=O)=O

InChiKey: MOUNHKKCIGVIDI-UHFFFAOYSA-L

InChi: InChI=1S/C21H16N2O9S2.2Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;/q;2*+1/p-2

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM, Water up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

AMI-1 was used at 10-30 µM final concentration in vitro and in cellular assays.

In Vivo:

AMI-1 was dosed by intranasal injection to Chronic AIPI rats at 50 μL (concentration of 0.1 mg/mL).

References:

1. Cheng D, et al. Small molecule regulators of protein arginine methyltransferases. (2004) J Biol Chem. 279(23):23892-9.
2. Sun Q, et al. PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation. (2015) J Immunol. 195(1):298-306.

Products are for research use only. Not for human use.