详情描述
AS8351 is a potent iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B) by competing with a-ketoglutarate. KDM5B a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. It can induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR99021, A83-01, BIX01294, SC1, Y-27632, OAC2, SU16f and JNJ10198409.
Product information
CAS Number: 796-42-9
Molecular Weight: 291.30
Formula: C17H13N3O2
Chemical Name: 2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone
Smiles: OC1=CC=C2C=CC=CC2=C1C=NNC(=O)C1C=CN=CC=1
InChiKey: WQSHHAVECQJKLX-YBFXNURJSA-N
InChi: InChI=1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
In Vitro:
AS8351 was used at 1-10 µM in vitro and cellular assays.
References:
- Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by 小分子化合物，新品. (2016) Science. 352(6290):1216-20.
Products are for research use only. Not for human use.