（-）-JQ-1

（-）-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (-)-JQ-1 Enantiomer has no effect.

Product information

CAS Number: 1268524-71-5

Molecular Weight: 456.99

Formula: C23H25ClN4O2S

Chemical Name: 6H-Thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2, 3, 9-trimethyl-, 1, 1-dimethylethyl ester, (6R)-

Smiles: CC1=NN=C2[C@@H](CC(=O)OC(C)(C)C)N=C(C3=C(SC(C)=C3C)N12)C1C=CC(Cl)=CC=1

InChiKey: DNVXATUJJDPFDM-QGZVFWFLSA-N

InChi: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: ≥ 22.8mg/mL in DMSO, ≥ 46.9 mg/mL in EtOH with ultrasonic

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

(-)-JQ-1 Enantiomer shows no significant interaction with any bromodomain. Besides, (-)-JQ-1 Enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC).

References:

1. Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
2. Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163.

Products are for research use only. Not for human use.