3'-O-Methylguanosine

3'-O-Methylguanosine, also known as 3-OMG, is a methylated nucleoside analog and a RNA chain terminator. Early virus-​specific RNA synthesis was preferentially inhibited by 3'-​O-​methyl guanosine.

Product information

CAS Number: 10300-27-3

Molecular Weight: 297.27

Formula: C11H15N5O5

Synonym:

NSC-106541

OMG

NSC 106541

NSC106541

3'-O-Methylguanosine

Chemical Name: 2-amino-9-((2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one

Smiles: CO[C@@H]1[C@@H](CO)O[C@H]([C@@H]1O)N1C=NC2=C1NC(N)=NC2=O

InChiKey: UYARPHAXAJAZLU-KQYNXXCUSA-N

InChi: InChI=1S/C11H15N5O5/c1-20-7-4(2-17)21-10(6(7)18)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Yang H, Wang D, Engelstad K, Bagay L, Wei Y, Rotstein M, Aggarwal V, Levy B, Ma L, Chung WK, De Vivo DC. Glut1 deficiency syndrome and erythrocyte glucose uptake assay. Ann Neurol. 2011 Dec;70(6):996-1005.
2. Fung EL, Ho YY, Hui J, Wong JH, Ng TB, Fong NY, Klepper J, Tsui KW. First report of GLUT1 deficiency syndrome in Chinese patients with novel and hot spot mutations in SLC2A1 gene. Brain Dev. 2011 Feb;33(2):170-3.
3. Deane AM, Nguyen NQ, Stevens JE, Fraser RJ, Holloway RH, Besanko LK, Burgstad C, Jones KL, Chapman MJ, Rayner CK, Horowitz M. Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia. J Clin Endocrinol Metab. 2010 Jan;95(1):215-21.

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