Benpyrine racemate

(Rac)-Benpyrine is a racemate of Benpyrine. (Rac)-Benpyrine is a potent and orally active TNF-α inhibitor and has the potential for TNF-α mediated inflammatory and autoimmune disease research.

Product information

CAS Number: 1333714-43-4

Molecular Weight: 308.34

Formula: C16H16N6O

Synonym:

MCULE-9046970117

Benpyrine racemate

1333714-43-4

AKOS033059553

Z1124160693

Chemical Name: 4-((9H-purin-6-yl)amino)-1-benzylpyrrolidin-2-one

Smiles: O=C1CC(CN1CC1C=CC=CC=1)NC1N=CN=C2NC=NC=12

InChiKey: HUWOMAVUXTXEKT-UHFFFAOYSA-N

InChi: InChI=1S/C16H16N6O/c23-13-6-12(8-22(13)7-11-4-2-1-3-5-11)21-16-14-15(18-9-17-14)19-10-20-16/h1-5,9-10,12H,6-8H2,(H2,17,18,19,20,21)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

(Rac)-Benpyrine (Compound 001; 5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages.

In Vivo:

(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction.

References:

1. Hua Li, et al. Compound with TNF- α inhibitory activity and application. CN111320630A.

Products are for research use only. Not for human use.