FMF-04-159-2

FMF-04-159-2 is a potent covalent CDK14 and CDK16 inhibitor. It also inhibits other TAIRE kinase family members.

Product information

CAS Number: 2364489-81-4

Molecular Weight: 683.01

Formula: C28H30Cl3N7O5S

Synonym:

FMF041592

FMF-04-159-2

FMF 04 159 2

Chemical Name: (E)-N-(1-((3-(4-(dimethylamino)but-2-enamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide

Smiles: CN(C)C/C=C/C(=O)NC1=CC(=CC=C1)S(=O)(=O)N1CCC(CC1)NC(=O)C1=NNC=C1NC(=O)C1C(Cl)=CC(Cl)=CC=1Cl

InChiKey: HZPYSAHDRSBARR-QPJJXVBHSA-N

InChi: InChI=1S/C28H30Cl3N7O5S/c1-37(2)10-4-7-24(39)33-19-5-3-6-20(15-19)44(42,43)38-11-8-18(9-12-38)34-28(41)26-23(16-32-36-26)35-27(40)25-21(30)13-17(29)14-22(25)31/h3-7,13-16,18H,8-12H2,1-2H3,(H,32,36)(H,33,39)(H,34,41)(H,35,40)/b7-4+

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

FMF-04-159-2 inhibits HCT116 proliferation with an IC50 of 1, 144±190 nM.

References:

1. Ferguson FM, et al. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4.

Products are for research use only. Not for human use.