LY 2886721 Hydrochloride

LY 2886721 Hydrochloride is a potent and selective β-secretase inhibitor.

Product information

CAS Number: 1262036-49-6

Molecular Weight: 426.87

Formula: C18H17ClF2N4O2S

Synonym:

LY 2886721 Hydrochloride

BS-14794

LY-2886721 hydrochloride

1262036-49-6

UNII-HW8GJY7V7R

HW8GJY7V7R

N-(3-((4aS,7aS)-2-Amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide hydrochloride

SCHEMBL970474

DTXSID10155116

BCP24785

Q27280128

Chemical Name: N-(3-((4aS,7aS)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-fluoropicolinamide hydrochloride

Smiles: Cl.NC1=N[C@]2(COC[C@H]2CS1)C1=CC(=CC=C1F)NC(=O)C1=CC=C(F)C=N1

InChiKey: JHHMCINLHBUFHB-GHDSXOKHSA-N

InChi: InChI=1S/C18H16F2N4O2S.ClH/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18;/h1-6,10H,7-9H2,(H2,21,24)(H,23,25);1H/t10-,18-;/m0./s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. May et al (2015) The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs and humans. J.Neurosci. 35 1199 PMID: 25609634

Products are for research use only. Not for human use.