(R)-(-)-Rolipram

(R)-(-)-rolipram R-enantiomer of rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 022 M and 25-fold more potent than-rolipram IC50 258 M in inhibiting membrane-bound PDE 4

Product information

CAS Number: 85416-75-7

Molecular Weight: 275.34

Formula: C16H21NO3

Synonym:

(R)-Rolipram

(-)-Rolipram

Chemical Name: (4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

Smiles: COC1=CC=C(C=C1OC1CCCC1)[C@H]1CC(=O)NC1

InChiKey: HJORMJIFDVBMOB-LBPRGKRZSA-N

InChi: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (363.19 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The increase of cAMP synthesis with the adenylate cyclase activator forskolin or the decrease of cAMP hydrolysis by the phosphodiesterase inhibitors Isobutylmethylxanthine (IBMX) and (R)-(-)-Rolipram (MedChem Express) suppresses caspase-1 cleavage and IL-1β secretion in a dose-dependent manner.

References:

1. Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944.

Products are for research use only. Not for human use.