BAY-885

BAY-885 is a highly potent and selective ERK5 inhibitor.

Product information

CAS Number: 2307249-33-6

Molecular Weight: 515.53

Formula: C25H28F3N7O2

Chemical Name: [2-amino-4-(trifluoromethoxy)phenyl]-[4-[7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl]piperidin-1-yl]methanone

Smiles: CN1CCN(CC1)C1=CN=C2C(=NC=NC2=C1)C1CCN(CC1)C(=O)C1=CC=C(C=C1N)OC(F)(F)F

InChiKey: QXURFIGBRGWPQD-UHFFFAOYSA-N

InChi: InChI=1S/C25H28F3N7O2/c1-33-8-10-34(11-9-33)17-12-21-23(30-14-17)22(32-15-31-21)16-4-6-35(7-5-16)24(36)19-3-2-18(13-20(19)29)37-25(26,27)28/h2-3,12-16H,4-11,29H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 30 mg/mL (58.19 mM) Ethanol 8 mg/mL (15.52 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BAY-885 shows potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and has no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM), thereby ruling out potential effects as a general inhibitor of transcription or translation.

References:

1. Duy Nguyen, et al. J Med Chem. 2019 Jan 24;62(2):928-940.

Products are for research use only. Not for human use.