详情描述
COH000 is an allosteric, covalent and irreversible ubiquitin-like 1-activating enzyme (SUMO-activating enzyme / E1) inhibitor with IC50 of 0.2 μM for SUMOylation in vitro.
Product information
CAS Number: 1534358-79-6
Molecular Weight: 419.47
Formula: C25H25NO5
Chemical Name: dimethyl 1-((R)-1-(phenylamino)-2-(p-tolyl)ethyl)-7-oxabicyclo [2.2.1]hepta-2,5-diene-2,3-dicarboxylate
Smiles: CC1C=CC(C[C@@H](NC2C=CC=CC=2)C23C=CC(O2)C(=C3C(=O)OC)C(=O)OC)=CC=1
InChiKey: UFPINDDCTUCUSA-ABGUIGEDSA-N
InChi: InChI=1S/C25H25NO5/c1-16-9-11-17(12-10-16)15-20(26-18-7-5-4-6-8-18)25-14-13-19(31-25)21(23(27)29-2)22(25)24(28)30-3/h4-14,19-20,26H,15H2,1-3H3/t19?,20-,25?/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO 50 mg/mL (119.20 mM) Ethanol 1 mg/mL (2.38 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Yi-Jia Li, et al. Cell Chem Biol. 2019 Feb 21;26(2):278-288.e6.
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