CB-103

CB-103 is an orally active inhibitor of the Notch transcription activation complex. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts.

Product information

CAS Number: 218457-67-1

Molecular Weight: 242.32

Formula: C15H18N2O

Synonym:

CB 103

CB103

Chemical Name: 5-Amino-2-(4-tert-butylphenoxy)pyridine

Smiles: CC(C)(C)C1C=CC(=CC=1)OC1=CC=C(N)C=N1

InChiKey: WHIWGRCYMQLLAO-UHFFFAOYSA-N

InChi: InChI=1S/C15H18N2O/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14/h4-10H,16H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 48 mg/mL (198.09 mM) Ethanol 48 mg/mL (198.09 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CB-103 inhibits growth of Notch-addicted human T cell acute lymphoblastic leukemia cell lines through modulation of the Notch transcription complex.

In Vivo:

CB-103 function in vivo recapitulates genetic notch loss-of-function phenotypes without causing gut toxicity. CB-103 blocks tumor growth of GSI-resistant cancers.

References:

1. Rajwinder Lehal, et al. Proc Natl Acad Sci U S A. 2020 Jul 14;1

Products are for research use only. Not for human use.