详情描述
CAY10505 is a phosphatidylinositol 3-kinase-γ inhibitor , was found to significantly improve acetylcholine-induced endothelium dependent relaxation, serum nitrate and (or) nitrite level, glutathione level, and the vascular endothelial lining in hypertensive rats. CAY10505 , may improve hypertension-associated vascular endothelial dysfunction. Inhibition of PI3Kγ might be a useful approach in the therapeutics of vascular endothelium dysfunction.
Product information
CAS Number: 1218777-13-9
Molecular Weight: 289.28
Formula: C14H8FNO3S
Synonym:
CAY 10505
Chemical Name: (E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2, 4-dione
Smiles: O=C1NC(=O)/C(=C\C2=CC=C(O2)C2C=CC(F)=CC=2)/S1
InChiKey: UFBTYTGRUBUUIL-KPKJPENVSA-N
InChi: InChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 58 mg/mL(200.49 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Sun YY, et al. PLoS One, 2013, 8(7):e69019.
Products are for research use only. Not for human use.