Yohimbine Hydrochloride

Yohimbine Hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.

Product information

CAS Number: 65-19-0

Molecular Weight: 390.90

Formula: C21H27ClN2O3

Synonym:

Yohimbine

Yohimbin

Corynine

Quebrachin

Quebrachine

Yohimex

Yocon

APHRODINE

(+)-Yohimbine

Aphrodyne

Aphrosol

Johimbin

Yohimbic acid methyl ester

Actibine

Thybine

Yohimar

Yovital

Yoman

Dayto himbin

Related CAS Number:

146-48-5 (Yohimbine)

Chemical Name: methyl (1S, 15R, 18S, 19R, 20S)-18-hydroxy-3, 13-diazapentacyclo[11.8.0.0, .0, .0, ]henicosa-2(10), 4(9), 5, 7-tetraene-19-carboxylate hydrochloride

Smiles: Cl.COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCC4C5=CC=CC=C5NC=4[C@@H]3C[C@@H]21

InChiKey: PIPZGJSEDRMUAW-VJDCAHTMSA-N

InChi: InChI=1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17-,18-,19+;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Yohimbine(Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. Yohimbine is a pre-synaptic alpha 2-adrenergic blocking agent. Yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei.

In Vivo:

LD50: Mice 55mg/kg (i.p.)

References:

1. Wink M, et al. J Chem Ecol, 1998, 24(11), 1881-1937
2. Banihashemi L, et al. J Neurosci, 2006, 26(44), 11442-11453.
3. Ernst E, et al. J Urol, 1998, 159(2), 433-436.

Products are for research use only. Not for human use.