详情描述
Chemical dimerizer used in auxin-inducible degron (AID) systems. Induces degradation of a target protein tagged with the auxin-receptor F-box protein Tir1 E3 ligase AID in human colorectral cancer and mouse ES cells or tagged with AFB2 in A431 cells. Endogenous plant hormone.
Product information
CAS Number: 87-51-4
Molecular Weight: 175.18
Formula: C10H9NO2
Synonym:
indolylacetic acid
1H-Indole-3-acetic acid
indoleacetic acid
heteroauxin
IAA
Chemical Name: indole-3-acetic acid
Smiles: OC(=O)CC1=CNC2=CC=CC=C21
InChiKey: SEOVTRFCIGRIMH-UHFFFAOYSA-N
InChi: InChI=1S/C10H9NO2/c12-10(13)5-7-6-11-9-4-2-1-3-8(7)9/h1-4,6,11H,5H2,(H,12,13)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 35 mg/mL(199.79 mM). Water: undefined.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Indole-3-acetic acid (IAA) induces cytotoxicity in fibroblasts, neutrophils, and several cancer lineages in vitro.
In Vivo:
IAA administration in pregnant rats during days 12-14 might selectively affect the S phase neurons and lead to their apoptosis in the neuroepithelium. It induces microencephaly in rats.
References:
- Furukawa S, et al. Toxicol Pathol. 2004, 32(6):659-67.
Products are for research use only. Not for human use.