(S)-(-)-5-Fluorowillardiine hydrochloride

(S)-(-)-5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist.

Product information

CAS Number: 1321546-70-6

Molecular Weight: 253.62

Formula: C7H9ClFN3O4

Synonym:

(5S)-Fluorowillardiine hydrochloride

(S)-5-Fluorowillardiine hydrochloride

Chemical Name: (2S)-2-amino-3-(5-fluoro-2, 4-dioxo-1, 2, 3, 4-tetrahydropyrimidin-1-yl)propanoic acid hydrochloride

Smiles: Cl.N[C@@H](CN1C=C(F)C(=O)NC1=O)C(O)=O

InChiKey: TXWOAFHJFQTAEW-WCCKRBBISA-N

InChi: InChI=1S/C7H8FN3O4.ClH/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12;/h1,4H,2,9H2,(H,13,14)(H,10,12,15);1H/t4-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 6.67 mg/mL (26.30 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Hawkinson JE, et al. Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding. Eur J Pharmacol. 1997 Jun 25;329(2-3):213-21.
2. Kessler M, et al. Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators. Brain Res. 2006 Mar 3;1076(1):25-41.
3. Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77(4):573-82.

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