AGN 205327

AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR. IC50 value: 3766/734/32 nM for RARα/β/γ Target: RAR agonist.

Product information

CAS Number: 2070018-29-8

Molecular Weight: 390.47

Formula: C24H26N2O3

Synonym:

AGN205327

AGN-205327

Chemical Name: (2Z)-2-[(hydroxyamino)(5, 5, 8, 8-tetramethyl-5, 6, 7, 8-tetrahydronaphthalen-2-yl)methylidene]-2H-indole-5-carboxylic acid

Smiles: CC1(C)CCC(C)(C)C2=CC(=CC=C12)C(NO)=C1C=C2C=C(C=CC2=N1)C(O)=O

InChiKey: NAFUJANSSZIADT-QZQOTICOSA-N

InChi: InChI=1S/C24H26N2O3/c1-23(2)9-10-24(3,4)18-12-14(5-7-17(18)23)21(26-29)20-13-16-11-15(22(27)28)6-8-19(16)25-20/h5-8,11-13,26,29H,9-10H2,1-4H3,(H,27,28)/b21-20+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Brown G, Hughes P. Retinoid differentiation therapy for common types of acute myeloid leukemia. Leuk Res Treatment. 2012;2012:939021.

Products are for research use only. Not for human use.