AGN 205728

AGN 205728 is a potent and selective RARγ antagonist.

Product information

CAS Number: 859498-05-8

Molecular Weight: 437.53

Formula: C29H27NO3

Synonym:

AGN205728

AGN-205728

Chemical Name: 4-[(1E,3E)-3-[8,8-dimethyl-5-(4-methylphenyl)-7,8-dihydronaphthalen-2-yl]-3-(hydroxyimino)prop-1-en-1-yl]benzoic acid

Smiles: CC1C=CC(=CC=1)C1=CCC(C)(C)C2=CC(=CC=C12)/C(/C=C/C1C=CC(=CC=1)C(O)=O)=N/O

InChiKey: AUKGBKLQWDXBEP-FSLFYVJCSA-N

InChi: InChI=1S/C29H27NO3/c1-19-4-9-21(10-5-19)24-16-17-29(2,3)26-18-23(13-14-25(24)26)27(30-33)15-8-20-6-11-22(12-7-20)28(31)32/h4-16,18,33H,17H2,1-3H3,(H,31,32)/b15-8+,30-27+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Tsang, Kwok Yin, et al. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity. Appl. (2005), WO 2005066115 A2 20050721.

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