详情描述
CNX-774 is a potent Btk inhibitor (IC50 < 1 nM). Recently Bruton's tyrosine kinase (BTK) , a crucial terminal kinase enzyme in the B-cell antigen receptor (BCR) signaling pathway, has emerged as an attractive target for therapeutic intervention in human malignancies and autoimmune disorders.
Product information
CAS Number: 1202759-32-7
Molecular Weight: 499.50
Formula: C26H22FN7O3
Chemical Name: 4-{4-[(5-fluoro-4-{[3-(prop-2-enamido)phenyl]amino}pyrimidin-2-yl)amino]phenoxy}-N-methylpyridine-2-carboxamide
Smiles: CNC(=O)C1=CC(=CC=N1)OC1C=CC(=CC=1)NC1=NC(NC2=CC(=CC=C2)NC(=O)C=C)=C(F)C=N1
InChiKey: VVLHQJDAUIPZFH-UHFFFAOYSA-N
InChi: InChI=1S/C26H22FN7O3/c1-3-23(35)31-17-5-4-6-18(13-17)32-24-21(27)15-30-26(34-24)33-16-7-9-19(10-8-16)37-20-11-12-29-22(14-20)25(36)28-2/h3-15H,1H2,2H3,(H,28,36)(H,31,35)(H2,30,32,33,34)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.