详情描述
EG-00229 trifluoroacetate is a Neuropilin 1 (NRP1) receptor antagonist which inhibits the binding of VEGFA to the NRP1 b1 domain. EG-00229 TFA has no effect on the binding of VEGFA to VEGFR-1 and VEGFR-2. EG-00229 TFA reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation, attenuates VEGFA-induced HUVEC cell migration, and reduces A549 lung carcinoma cell viability in vitro.
Product information
CAS Number: 1210945-69-9
Molecular Weight: 611.60
Formula: C19H20F3N7O7S3
Chemical Name: (2S)-2-{[3-(2,1,3-benzothiadiazole-4-sulfonamido)thiophen-2-yl]formamido}-5-[(diaminomethylidene)amino]pentanoic acid; trifluoroacetic acid
Smiles: NC(N)=NCCC[C@H](NC(=O)C1SC=CC=1NS(=O)(=O)C1=CC=CC2=NSN=C21)C(O)=O.OC(=O)C(F)(F)F
InChiKey: ZYQBITUOSRZDTG-MERQFXBCSA-N
InChi: InChI=1S/C17H19N7O5S3.C2HF3O2/c18-17(19)20-7-2-4-11(16(26)27)21-15(25)14-10(6-8-30-14)24-32(28,29)12-5-1-3-9-13(12)23-31-22-9;3-2(4,5)1(6)7/h1,3,5-6,8,11,24H,2,4,7H2,(H,21,25)(H,26,27)(H4,18,19,20);(H,6,7)/t11-;/m0./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.