详情描述
BC1618 is an orally active Fbxo48 inhibitor that stimulates adenosine monophosphate (AMP)-activated protein kinase (Ampk)-dependent signaling. BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity.
Product information
CAS Number: 2222094-18-8
Molecular Weight: 415.45
Formula: C24H24F3NO2
Chemical Name: 1-(dibenzylamino)-3-(4-(trifluoromethyl)phenoxy)propan-2-ol
Smiles: OC(COC1C=CC(=CC=1)C(F)(F)F)CN(CC1C=CC=CC=1)CC1C=CC=CC=1
InChiKey: LGTYABNNHILKHF-UHFFFAOYSA-N
InChi: InChI=1S/C24H24F3NO2/c25-24(26,27)21-11-13-23(14-12-21)30-18-22(29)17-28(15-19-7-3-1-4-8-19)16-20-9-5-2-6-10-20/h1-14,22,29H,15-18H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 83 mg/mL(199.78 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
BC1618 interrupts Fbxo48/pAmpkα interaction. BC1618 facilitates mitochondrial fission and autophagy.
In Vivo:
Consistent with augmenting Ampk activity, BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice.
References:
- Yuan Liu, et al. Nat Chem Biol. 2021 Mar;17(3):298-306.
Products are for research use only. Not for human use.