Nutlin-C1-amido-PEG4-C2-N3

Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology.

Product information

CAS Number: 2369022-70-6

Molecular Weight: 883.82

Formula: C42H52Cl2N8O9

Synonym:

MDM2 Ligand-Linker Conjugates 1

E3 ligase Ligand-Linker Conjugates 48

Chemical Name: N-(14-azido-3, 6, 9, 12-tetraoxatetradecan-1-yl)-2-{4-[(4R, 5S)-4, 5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4, 5-dihydro-1H-imidazole-1-carbonyl]-2-oxopiperazin-1-yl}acetamide

Smiles: CC(C)OC1=CC(=CC=C1C1=N[C@@H]([C@H](C2C=CC(Cl)=CC=2)N1C(=O)N1CC(=O)N(CC(=O)NCCOCCOCCOCCOCCN=[N+]=[N-])CC1)C1C=CC(Cl)=CC=1)OC

InChiKey: YLHONJUOEKAZKP-PVXQIPPMSA-N

InChi: InChI=1S/C42H52Cl2N8O9/c1-29(2)61-36-26-34(56-3)12-13-35(36)41-48-39(30-4-8-32(43)9-5-30)40(31-6-10-33(44)11-7-31)52(41)42(55)51-17-16-50(38(54)28-51)27-37(53)46-14-18-57-20-22-59-24-25-60-23-21-58-19-15-47-49-45/h4-13,26,29,39-40H,14-25,27-28H2,1-3H3,(H,46,53)/t39-,40+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Gu S, et al. PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery. Bioessays. 2018 Apr;40(4):e1700247.

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