ATRA-hydroxyimino

ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA)-based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II in IMR-32 cells.

Product information

CAS Number: 135325-47-2

Molecular Weight: 329.43

Formula: C20H27NO3

Synonym:

CRABP-II ligand 1

Chemical Name: (2E, 4E, 6E)-9-[(3E)-3-(hydroxyimino)-2, 6, 6-trimethylcyclohex-1-en-1-yl]-3, 7-dimethylnona-2, 4, 6, 8-tetraenoic acid

Smiles: C/C(/C=CC1=C(C)/C(/CCC1(C)C)=N/O)=C\C=C\C(\C)=C\C(O)=O |t:2|

InChiKey: TXLVFISHOZJIQV-WYIJURDSSA-N

InChi: InChI=1S/C20H27NO3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21-24)11-12-20(17,4)5/h6-10,13,24H,11-12H2,1-5H3,(H,22,23)/b8-6+,10-9+,14-7+,15-13+,21-18+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.

Products are for research use only. Not for human use.