详情描述
H2N-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Product information
CAS Number: 134978-97-5
Molecular Weight: 163.17
Formula: C6H13NO4
Chemical Name: 2-[2-(2-aminoethoxy)ethoxy]acetic acid
Smiles: NCCOCCOCC(O)=O
InChiKey: RUVRGYVESPRHSZ-UHFFFAOYSA-N
InChi: InChI=1S/C6H13NO4/c7-1-2-10-3-4-11-5-6(8)9/h1-5,7H2,(H,8,9)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.
Products are for research use only. Not for human use.