Lestaurtinib

Lestaurtinib (CEP-701;KT-5555) is an ATP-competitive multi-kinase inhibitor with potent activity against the Trk family of receptor tyrosine kinases. Lestaurtinib inhibits JAK2, FLT3 and TrkA with IC50s of 0.9, 3 and less than 25 nM, respectively.

Product information

CAS Number: 111358-88-4

Molecular Weight: 439.46

Formula: C26H21N3O4

Synonym:

CEP-701

KT-5555

Chemical Name: (15S, 16S, 18R)-16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4, 14, 19-triazaoctacyclo[12.11.2.1, .0, .0, .0, .0, .0, ]octacosa-1, 6, 8, 10, 12, 20, 22, 24, 26-nonaen-3-one

Smiles: C[C@]12O[C@H](C[C@]1(O)CO)N1C3=C4C(=C5CNC(=O)C5=C3C3=CC=CC=C13)C1=CC=CC=C1N24

InChiKey: UIARLYUEJFELEN-LROUJFHJSA-N

InChi: InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (113.78 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Miknyoczki SJ, et al. The novel Trk receptor tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits antitumor efficacy against human pancreatic carcinoma (Panc1) xenograft growth and in vivo invasiveness. Ann N Y Acad Sci. 1999 Jun 30;880:252-62.

Products are for research use only. Not for human use.