FM-479

FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

Product information

CAS Number: 2226521-64-6

Molecular Weight: 442.51

Formula: C25H26N6O2

Chemical Name: (2E)-2-cyano-3-(5-{3-cyclohexyl-10-methyl-3, 5, 8, 10-tetraazatricyclo[7.3.0.0, ]dodeca-1, 4, 6, 8, 11-pentaen-4-yl}furan-2-yl)-N, N-dimethylprop-2-enamide

Smiles: CN(C)C(=O)/C(=C/C1=CC=C(O1)C1=NC2=CN=C3C(C=CN3C)=C2N1C1CCCCC1)/C#N

InChiKey: RPIGHLXKDWUGDT-DTQAZKPQSA-N

InChi: InChI=1S/C25H26N6O2/c1-29(2)25(32)16(14-26)13-18-9-10-21(33-18)24-28-20-15-27-23-19(11-12-30(23)3)22(20)31(24)17-7-5-4-6-8-17/h9-13,15,17H,4-8H2,1-3H3/b16-13+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

FM-479 is the inactive control of FM-381, the concentration used in assays is similar.

References:

1. https://www.thesgc.org/chemical-probes/FM-381

Products are for research use only. Not for human use.