ROCK-IN-1

ROCK-IN-1 is a potent inhibitor of ROCK, with an IC50 of 1.2 nM for ROCK2.

Product information

CAS Number: 934387-35-6

Molecular Weight: 335.37

Formula: C20H18FN3O

Chemical Name: 6-(1-aminoethyl)-4'-fluoro-N-(pyridin-4-yl)-[1, 1'-biphenyl]-3-carboxamide

Smiles: CC(N)C1=CC=C(C=C1C1C=CC(F)=CC=1)C(=O)NC1C=CN=CC=1

InChiKey: JJNXXPMAFUVGRU-UHFFFAOYSA-N

InChi: InChI=1S/C20H18FN3O/c1-13(22)18-7-4-15(20(25)24-17-8-10-23-11-9-17)12-19(18)14-2-5-16(21)6-3-14/h2-13H,22H2,1H3,(H,23,24,25)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ROCK-IN-1 shows potent cellular efficacy, with an EC50 of 200 nM.

References:

1. Boland S, et al. 3-[2-(Aminomethyl)-5-[(pyridin-4-yl)carbamoyl]phenyl] benzoates as soft ROCK inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6442-6.

Products are for research use only. Not for human use.