Muscotoxin A

Muscotoxin A is an ADC cytotoxin. Muscotoxin A is a cytotoxic lipopeptide that permeabilizes mammalian cell membranes and induces necrotic cell death.

Product information

CAS Number: 1653999-47-3

Molecular Weight: 1211.41

Formula: C58H90N12O16

Chemical Name: 3-[(6R, 13S, 19R, 22S, 25Z, 28S, 31R, 34S, 37S)-34-benzyl-19, 31-bis[(2S)-butan-2-yl]-25-ethylidene-9-hydroxy-10-(2-hydroxyheptyl)-22, 28-bis(hydroxymethyl)-2, 5, 8, 12, 18, 21, 24, 27, 30, 33, 36-undecaoxo-1, 4, 7, 11, 17, 20, 23, 26, 29, 32, 35-undecaazatricyclo[35.3.0.0, ]tetracontan-6-yl]propanamide

Smiles: C/C=C1\NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC2C=CC=CC=2)NC(=O)[C@@H]2CCCN2C(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)C(O)C(CC(O)CCCCC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](CO)NC\1=O)[C@@H](C)CC)[C@@H](C)CC

InChiKey: WYLYXGBHDIWORI-BSACXQMXSA-N

InChi: InChI=1S/C58H90N12O16/c1-7-11-13-20-35(73)28-38-48(76)57(85)62-37(23-24-44(59)74)49(77)60-29-45(75)69-25-16-21-42(69)54(82)64-39(27-34-18-14-12-15-19-34)51(79)67-46(32(5)8-2)56(84)66-40(30-71)52(80)61-36(10-4)50(78)65-41(31-72)53(81)68-47(33(6)9-3)58(86)70-26-17-22-43(70)55(83)63-38/h10,12,14-15,18-19,32-33,35,37-43,46-48,71-73,76H,7-9,11,13,16-17,20-31H2,1-6H3,(H2,59,74)(H,60,77)(H,61,80)(H,62,85)(H,63,83)(H,64,82)(H,65,78)(H,66,84)(H,67,79)(H,68,81)/b36-10-/t32-,33-,35?,37+,38?,39-,40-,41-,42-,43-,46+,47+,48?/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Muscotoxin A (0-13.2 μM ; 24 hours) is cytotoxic to YAC-1, Sp/2, and HeLa cancer cell lines (LC50) ranged from 9.9 to 13.2 μM, causing membrane damage and influx of calcium ions.

References:

1. Petr Tomek, et al. Cytotoxic Lipopeptide Muscotoxin A, Isolated From Soil Cyanobacterium Desmonostoc Muscorum, Permeabilizes Phospholipid Membranes by Reducing Their Fluidity. Chem Res Toxicol. 2015 Feb 16;28(2):216-24.

Products are for research use only. Not for human use.