(Z)-GW 5074

(Z)-GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder.

Product information

CAS Number: 1233748-60-1

Molecular Weight: 520.94

Formula: C15H8Br2INO2

Chemical Name: (3Z)-3-[(3, 5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one

Smiles: OC1C(Br)=CC(=CC=1Br)C=C1C(=O)NC2=CC=C(I)C=C21

InChiKey: LMXYVLFTZRPNRV-KMKOMSMNSA-N

InChi: InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.

Products are for research use only. Not for human use.