Aloperine

Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells.

Product information

CAS Number: 56293-29-9

Molecular Weight: 232.36

Formula: C15H24N2

Chemical Name: (1R, 2S, 9R, 10R)-3, 15-diazatetracyclo[7.7.1.0, .0, ]heptadec-7-ene

Smiles: C1[C@@H]2C=C3CCCN[C@H]3[C@H]1CN1CCCC[C@@H]12

InChiKey: SKOLRLSBMUGVOY-GBJTYRQASA-N

InChi: InChI=1S/C15H24N2/c1-2-7-17-10-13-9-12(14(17)5-1)8-11-4-3-6-16-15(11)13/h8,12-16H,1-7,9-10H2/t12-,13+,14+,15+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 100 mg/mL (430.37 mM; Need ultrasonic) DMSO : 31.25 mg/mL (134.49 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Aloperine (1-20 mM; 24 hours) gives growth-inhibitory IC50 values in cancer cells ranges from 0.04 to 1.36 mM, the IC50 values in HL-60, U937, K562, EC109, A549 and HepG2 cells are 0.04, 0.27, 0.36, 1.11, 1.18 and 1.36 mM, respectively. Aloperine (1-20 mM; 24 hours) induces apoptosis and decreases bcl-2 expression in HL-60 cells. Aloperine (20–100 mM; 18 hours) induces autophagy and formation of acidic vacuole in HL-60 cells.

References:

1. Lin Z, et al. In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait. Basic Clin Pharmacol Toxicol. 2011 May;108(5):304-9.
2. Yuan XY, et al. Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice. Eur J Pharmacol. 2010 Mar 10;629(1-3):147-52.

Products are for research use only. Not for human use.