Decursin

Decursin ((+)-Decursin) is a cytotoxic agent and a potent protein kinase C activator from the Root of Angelica gigas. Decursin inhibits tumor growth, migration, and invasion in gastric cancer by down-regulating CXCR7 expression. Decursin inhibits the growth of HepG2 cells via Hippo/YAP signaling pathway.

Product information

CAS Number: 5928-25-6

Molecular Weight: 328.36

Formula: C19H20O5

Synonym:

(+)-Decursin

Chemical Name: (6S)-5, 5-dimethyl-13-oxo-4, 14-dioxatricyclo[8.4.0.0, ]tetradeca-1, 3(8), 9, 11-tetraen-6-yl 3-methylbut-2-enoate

Smiles: CC(C)=CC(=O)O[C@H]1CC2=CC3C=CC(=O)OC=3C=C2OC1(C)C

InChiKey: CUKSFECWKQBVED-INIZCTEOSA-N

InChi: InChI=1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (380.68 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Ahn KS,et al. Decursin: a cytotoxic agent and protein kinase C activator from the root of Angelica gigas. Planta Med. 1996;62(1):7-9.
2. Li J, et al. Decursin inhibits the growth of HepG2 hepatocellular carcinoma cells via Hippo/YAP signaling pathway. Phytother Res. 2018;32(12):2456-2465.
3. Kim S, et al. Decursin inhibits tumor growth, migration, and invasion in gastric cancer by down-regulating CXCR7 expression. Am J Cancer Res. 2019;9(9):2007-2018. Published 2019 Sep 1.

Products are for research use only. Not for human use.